Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous system CNS. In most cases, gliosis involves the proliferation or hypertrophy of several different types of glial cells, including astrocytes , microglia , and oligodendrocytes. In its most extreme form, the proliferation associated with gliosis leads to the formation of a glial scar. The process of gliosis involves a series of cellular and molecular events that occur over several days. This process, which constitutes a form of gliosis known as microgliosis, begins within hours of the initial CNS injury. Gliosis has historically been given a negative connotation due to its appearance in many CNS diseases and the inhibition of axonal regeneration caused by glial scar formation.
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Encephalomalacia is term given to describe softening or loss of brain parenchyma with or without surrounding gliosis , as a late manifestation of injury. Encephalomalacia is the end result of liquefactive necrosis of brain parenchyma following insult, usually occurring after cerebral ischemia , cerebral infection , hemorrhage , traumatic brain injury, surgery or other insults. It is not synonymous with gliosis , which is the proliferation of glial cells in response to injury.
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On this page:. Encephalomalacia in the frontal lobe: complication of the endoscopic sinus surgery. J Craniofac Surg. Multicystic encephalomalacia: CT appearance and pathological correlation.
J Comput Assist Tomogr. Pubmed citation 3. Levine D. Case encephalomalacia in surviving twin after death of monochorionic co-twin. Multicystic encephalomalacia as an end-stage finding in abusive head trauma. Forensic Sci Med Pathol. Multicystic encephalomalacia in term infants. Child's Nerv Syst. Fundamentals of Diagnostic Radiology. Read it at Google Books - Find it at Amazon. Promoted articles advertising. Edit article Share article View revision history Report problem with Article.
URL of Article. Article information. System: Central Nervous System. Synonyms or Alternate Spellings: Encephalomalacias. Support Radiopaedia and see fewer ads.
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